New Amsterdam Genomics is powerful insightful life-changing

There are three main types of heart problems: arrhythmias, structural heart disease, and coronary heart disease. We check for genetic risks for all three. For example, we have identified patients who have rare cardiac defects. These people may have been at risk for effects as serious as sudden cardiac death, but with help from a cardiologist, they can potentially avoid this fate and live longer. Coronary heart disease is very different because it is so common and is caused by so many different factors. Some of the different factors we have identified in patients include risk of hypertension, high blood cholesterol, high homocysteine, and high lipoprotein(a). Understanding your biggest risk factors may allow your doctor to better manage your overall risk for coronary heart disease.

We can find the genetic basis of all sorts of chronic diseases including diabetes, asthma, autoimmune disease, multiple sclerosis, and more. (However, genetics does not cause every disease; some diseases are caused by a person's lifestyle or simply bad luck.) Understanding the basis of a chronic disease may unlock better ways to manage it. For example, diabetes is typically caused by a complex interaction between your genomics and environment (such as your diet and fitness habits). Our analysis can reveal the part played by your genomics, potentially enabling you to adjust your diet and fitness habits to optimally reduce your risk.

Some people are interested in learning if they are at risk for dementia or neurodegenerative problems as they age. We have helped many people determine their risk. In some cases, we have been able to propose possible mitigation steps. For example, you may have heard of ApoE4, which is one of the mutations most strongly related to Alzheimer's risk. But did you know there are several studies showing specific diets that may reduce risk of Alzheimer's in people who have this mutation? If you have parents or grandparents with dementia, understanding your risk and developing a plan to mitigate that risk could be very valuable to you.

Our platform can help identify unique aspects of you that you and your doctors may not have fully appreciated. For example, it is estimated that approximately 10% of people have a rare medical condition. Even though each rare condition is, by definition, rare in the population, there are so many rare conditions that it is not rare for a person to have one. Moreover, most rare conditions are not immediately life threatening, and knowing that you have something rare could answer important questions about your health. It may explain symptoms you have, and it could enable your doctors to manage your health better. We have helped patients with the most complicated situations, including fatigue, migraine, pain, autoimmune problems, gastrointestinal problems, unusual sensitivities, brain fog, dysautonomia, etc.

The genes in the Cytochrome P450 complex have some of the strongest impacts on why certain medications work differently in some people as compared to others. (Click here for a Wikipedia article on Cytochrome P450.) We analyze these genes plus many others to predict which medicines will work best for each person. We can even in some cases determine ideal dosages for medicines.

Have you ever wondered why certain diets work better for some people than others? There is exciting research happening right now that compares how different people perform on different diets, based on variations in their DNA. We have used these studies to suggest specific diets for people. These options may include the saturated fat diet (similar to Atkins), the monounsaturated fat diet (Mediterranean diet), and the high carbohydrate, low fat diet. Not just that, but sometimes there are specific foods (like watermelon or coffee) that are predicted to be good for people, depending on their specific genomic mutations.

Our fitness recommendations serve two valuable objectives. First, we can show you how different exercises improve your health. For instance, we have results that say aerobic exercise may be more or less likely to improve your insulin sensitivity, based on your genomics, and more or less likely to improve your VO2 max (a measure of lung function). Second, our fitness recommendations can reveal which athletic activities you are most likely to excel in, based on your unique biological advantages. This can help you become a better athlete, if you are so inclined.

There are many ways you can modulate your health beyond diet and fitness. For instance, did you know that studies have found that when you sleep, how you sleep, and how long you sleep can all be important modifies of your risk for certain types heart disease, cancer, and dementia? Among many other things, our test can help you optimize your sleep.

The average person carries multiple diseases in their DNA that they do not express themselves. Such diseases are called "recessive." These are not problems unless the person and their partner both carry the same recessive disease; in that case, the couple's children are at risk of becoming afflicted with that disease. Examples of recessive diseases include Cystic Fibrosis, Tay-Sachs disease, Familial Mediterranean fever, and Niemann-Pick disease. Recessive diseases can often be debilitating, so you really don't want your child to be afflicted. Therefore, even if you and your partner are completely healthy, it still can be a very good idea to check which recessive diseases you carry. To learn more about recessive diseases, here the US government has written a great explanation here.

Are you hoping to have a child? Test both you and your partner to learn 1) which recessive diseases you both carry (see above), 2) which rare X-linked mutations the female has (important if your future child is a boy), 3) if your future child has a risk for developmental problems early in life, and 4) if the female has any unusual risks for pregnancy.

Ancestry determination is included with our analysis. We compare your DNA with 52 different populations from around the globe. Which region of the world do your ancestors come from?