New Amsterdam Genomics

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Discovering what's in your DNA can unlock new opportunities to improve and optimize your health. Start today!

Individual in Focus

I Want to Reach My Health Potential!

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New Amsterdam Genomics is powerful insightful life-changing

We predict that by 2020, 20% of Americans will know their DNA. DNA sequencing will transform how people stay healthy. People will not have to react to symptoms; they will proactively prevent problems their DNA predisposes them to.

N.A.G. brings this "precision medicine" to life. We have created the world's premier DNA test, scanning all 22,000 genes of your DNA and cross-referencing them with more than 200,000 health-related findings. Whether you are healthy or sick, our test can potentially teach you valuable things about your health.

What Can I Learn from My Results?

Am I at risk of a serious medical problem, and can I do something today to stay healthier longer?
How can I tailor my diet, exercise, and lifestyle choices to optimize my health?
Which medicines, therapies, and supplements are safest and most effective for me?

Areas of Interest

You may have heard of the BRCA1 gene and its relation to breast cancer, but did you know that science has now identified more than 1000 genes that, like BRCA1, are strongly related to cancer risk? We are the only service that analyzes your cancer risk in terms of all of these genes. Even tests that focus specifically on cancer typically look at just 20-80 cancer genes (2-8% as many as us). Our information can direct the type of screening a person should receive, meaning cancer may be caught earlier and may be easier to treat. There have also been situations with people who already have cancer, for whom we have found special treatments based on their genomic mutations.
There are three main types of heart problems: arrhythmias, structural heart disease, and coronary heart disease. We check for genetic risks for all three. For example, we have identified patients who have rare cardiac defects. These people may have been at risk for effects as serious as sudden cardiac death, but with help from a cardiologist, they can potentially avoid this fate and live longer. Coronary heart disease is very different because it is so common and is caused by so many different factors. Some of the different factors we have identified in patients include risk of hypertension, high blood cholesterol, high homocysteine, and high lipoprotein(a). Understanding your biggest risk factors may allow your doctor to better manage your overall risk for coronary heart disease.
We can find the genetic basis of all sorts of chronic diseases including diabetes, asthma, autoimmune disease, multiple sclerosis, and more. (However, genetics does not cause every disease; some diseases are caused by a person's lifestyle or simply bad luck.) Understanding the basis of a chronic disease may unlock better ways to manage it. For example, diabetes is typically caused by a complex interaction between your genomics and environment (such as your diet and fitness habits). Our analysis can reveal the part played by your genomics, potentially enabling you to adjust your diet and fitness habits to optimally reduce your risk.
Some people are interested in learning if they are at risk for dementia or neurodegenerative problems as they age. We have helped many people determine their risk. In some cases, we have been able to propose possible mitigation steps. For example, you may have heard of ApoE4, which is one of the mutations most strongly related to Alzheimer's risk. But did you know there are several studies showing specific diets that may reduce risk of Alzheimer's in people who have this mutation? If you have parents or grandparents with dementia, understanding your risk and developing a plan to mitigate that risk could be very valuable to you.
Our platform can help identify unique aspects of you that you and your doctors may not have fully appreciated. For example, it is estimated that approximately 10% of people have a rare medical condition. Even though each rare condition is, by definition, rare in the population, there are so many rare conditions that it is not rare for a person to have one. Moreover, most rare conditions are not immediately life threatening, and knowing that you have something rare could answer important questions about your health. It may explain symptoms you have, and it could enable your doctors to manage your health better. For example, we have helped some people who have reported symptoms of fatigue: we have identified genetic causes of their fatigue, and, in some cases, found actions they can take that are predicted to alleviate their symptoms.
The genes in the Cytochrome P450 complex have some of the strongest impacts on why certain medications work differently in some people as compared to others. (Click here for a Wikipedia article on Cytochrome P450.) We analyze these genes plus many others to predict which medicines will work best for each person. We can even in some cases determine ideal dosages for medicines.
Have you ever wondered why certain diets work better for some people than others? There is exciting research happening right now that compares how different people perform on different diets, based on variations in their DNA. We have used these studies to suggest specific diets for people. These options may include the saturated fat diet (similar to Atkins), the monounsaturated fat diet (Mediterranean diet), and the high carbohydrate, low fat diet. Not just that, but sometimes there are specific foods (like watermelon or coffee) that are predicted to be good for people, depending on their specific genomic mutations.
Our fitness recommendations serve two valuable objectives. First, we can show you how different exercises improve your health. For instance, we have results that say aerobic exercise may be more or less likely to improve your insulin sensitivity, based on your genomics, and more or less likely to improve your VO2 max (a measure of lung function). Second, our fitness recommendations can reveal which athletic activities you are most likely to excel in, based on your unique biological advantages. This can help you become a better athlete, if you are so inclined.
The average person carries multiple diseases in their DNA that they do not express themselves. Such diseases are called "recessive." These are not problems unless the person and their partner both carry the same recessive disease; in that case, the couple's children are at risk of becoming afflicted with that disease. Examples of recessive diseases include Cystic Fibrosis, Tay-Sachs disease, Familial Mediterranean fever, and Niemann-Pick disease. Recessive diseases can often be debilitating, so you really don't want your child to be afflicted. Therefore, even if you and your partner are completely healthy, it still can be a very good idea to check which recessive diseases you carry. To learn more about recessive diseases, here the US government has written a great explanation here.
Ancestry determination is included with our analysis. We compare your DNA with 52 different populations from around the globe. Which region of the world do your ancestors come from?

The N.A.G. Difference

Whole Exome Sequencing

We analyze all 22,000 of your genes. Older tests, such as 23andMe, did what is called genotyping, which is looking at your DNA in just a few discrete places. Our approach provides a much broader view of your genome, and can even reveal rare mutations you may have.

Major Impacts

Earlier DNA tests generally only produced medical findings with small effect sizes (e.g. a 5% increased risk of something or a 10% decreased risk of something). We argue that these small findings are not very useful, because they probably would not change how you and your doctor manage your health. N.A.G., by contrast, routinely finds medical issues that people are multiple times higher risk for. The reason is that we are able to measure and make sense of very rare mutations.

Advanced Computer Analysis

N.A.G. was founded on the premise that analyzing billions of DNA measurements, as is done in large scale genomics, requires elite computer programming to be done right. We have some of the best programmers in the world, and they have created superior algorithms to analyze your DNA.

Comprehensive

We report on everything from significant medical findings to diet and exercise recommendations to ancestry. We report anything we can find about your DNA, so long as there is a peer-reviewed, published paper to back it up.

child after DNA analysis

Recommended by the Best

We are honored that some of the best doctors in the country have endorsed us. In total, more than 500 doctors offer N.A.G. for their patients.

New Amsterdam Genomics exome sequencing is the beginning of the future standard in which patients will have a genetic blueprint to help guide them and their physicians in day to day choices as well as customized plans for the prevention of illness.

Dr. Dirk FraterE. Barrow Medical Group -- Dallas, TX

Patients are empowered to become more engaged in their health and their future when they have the level of information that is available through genomic testing with NAG.

Dr. Edward S. GoldbergConcierge MD

This is one of the best preventive and discovery tools I have at my disposal today.

Dr. Thom LobeRegeneveda -- Chicago, IL

Get Started

Here's how to join the New Amsterdam Genomics program.

  1. Enter your contact information in the box below.
  2. Ask your doctor about our test. We can send you materials to show your doctor. Don't have a doctor? No problem. We will connect you with a great one in our network.
  3. We send a kit to your home with all the materials you need. Collect your saliva, and ship the kit back to us.
  4. DNA is extracted from your specimen, and the sequence (a list of A's, C's, G's, and T's) is determined over the entire protein coding region of your genome. N.A.G. runs sophisticated algorithms on your data to uncover meaning and impact.
  5. N.A.G. delivers to your doctor a report explaining your unique findings. You receive access to an online portal enabling you to investigate your results at every level of detail. Your doctor and you can now devise ways to optimize your health.

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